A Top Trainers’ Checklist Becoming and being a successful personal trainer or coach can be defined in a lot of different ways, by many different people. Some might argue that the defining characteristic of a top trainer is having a high number of daily, monthly, or yearly clients sessions. Others might peg a top trainer […]
Hallmarks of Aging – Role of Glycation Part 5: Loss of Proteostasis
Proteostasis, or protein homeostasis, is the successful quality control of the cells’ proteome (that is, the entire set of proteins expressed by a cell or organism at a given time). All proteins are subject to a variety of structural modifications post-translationally such as methylation, acetylation, and very often negatively, by glycation which goes on […]
Hallmarks of Aging Role of Glycation Part 4: Epigenetic Alterations
Epigenetics is a term used for gene expression modifications caused by heritable, but potentially reversible, changes in DNA linked processes. These processes include DNA methylations, modifications of histones and chromatin structural changes. DNA methylation modifies a DNA strand after replication. It is the addition of a CH3 (methyl group) to a nucleoside residue – […]
Hallmarks of Aging – Role of Glycation Part 3: Telomere/Telomerase Dysregulation
A chromosome is a long strand of DNA and associated proteins that carry and transmit genetic traits. At the end of a chromosome is a section of nucleotides called the telomere. Telomeres keep chromosomes “protected” and prevent them from combining into rings or linking with other DNA strands. Telomeres play an important role in cell […]
Hallmarks of Aging – Role of Glycation: Genomic Instability
Hallmarks of Aging – Role of Glycation Part 2: Genomic Instability by Nicholas Pokoluk If you like, start with part 1 here >>> and part 3 here >>> We have set the stage, in the first post of this series, for discussions of the role of glycation in the aging process by virtue of […]